Contents:
1. Antioxidant Nutrients and Protection From Free Radicals M. Doyle and M. Pariza 2. Carotenoids and Health Risk E. Kraczek and J. Erdman 3. The Role of Nutrients in Detoxification Mechanisms K. Netter 4. Foods Derived From Genetically Modified Crop Plants R. Fuchs 5. Allergic Reactions and Food Intolerances S. Taylor and S. Hefle 6. Ethanol Toxicity and Nutritional Status H. Seitz and P. Suter 7. Interactions Between Foods, Nutritional Supplements and Drugs J. Thomas and R. Cotter 8. Phytosterols in Human Health D. Kritchevsky 9. Threshhold of Regulation: A Unifying Concept in Food Safety Assessment W. Flamm, F. Kotsonis and J. Hjelle 10. Biotechnology-derived and Novel Foods: Safety Approaches and Regulations G. Speijers 11. Safety Effectiveness and Labelling of Self Care Products R. Soller 12. Functional Foods: Regulatory and Scientific Considerations M. Mackey and F. Kotsonis 13. Estimation of Food Chemical Intake D. Tennant and N, Rees 14. Post Marketing Surveillance in the Food Industry: the Aspartame Case Study H. Butchko and W. Stargel 15. Regulation of Flavour Ingredients G. Burdock 16. Food Irradiation P. Elias 17. Carcinogens M. McClain

This useful book reviews and analyzes the rigorous scientific, regulatory, and clinical testing and evaluation applied to the widely used food additive aspartame. In one compact volume you gain access to extensive information illustrating the increased recognition by regulatory agencies of the usefulness of human studies in evaluating new food additives. The Clinical Evaluation of a Food Additive: Assessment of Aspartame begins by describing the nuts and bolts of food additive safety evaluation in humans, including an insightful historical perspective of the development of good clinical practice guidelines. It provides the regulatory requirements for human research, as well as key elements for the design and conduct of human studies. The scientific and regulatory considerations of food additive safety are explored, including interesting descriptions of aspartame's key animal safety studies. In addition, the book reviews the medical postmarketing surveillance system developed for identifying and evaluating reports of aspartame's alleged adverse health effects. Through meticulous research and systematic clarity, The Clinical Evaluation of a Food Additive: Assessment of Aspartame provides work-saving, state-of-the-art examples to guide future testing and evaluation of tomorrow's food additives.

In ten essays commissioned by the NutraSweet Company, contributors from the health and food sciences explain to the general consumer that nutrition is not as simple as some people make it out to be, and there are still questions about sugar, cholesterol, obesity, and other topics. Annotation copyrig

Nutrients are gaining recognition for their role in protecting against the toxic effects of free radicals, alcohol and other substances. At the same time, advances in food technology, the appearance of novel foods and new ingredients have generated new toxicological issues and forced health and safety professionals to develop new and more reliable methods to assess their impact on our health. These issues are at the heart of the second edition of Nutritional Toxicology. The book discusses the role of nutrients in protecting the body against toxicants. It explores the overall importance of the metabolism of xenobiotics and antioxidant nutrients in their increasingly important role in protecting against oxidative damage generated by free radicals. The book also discusses components of the diet that can influence metabolism of drugs, how alcohol consumption affects nutritional status, and conversely, how nutritional status affects alcohol metabolism. The effect of age on the body's ability to metabolize drugs and toxicants is discussed in detail.